池毓烺，副教授，中國科學(xué)院大學(xué)博士，“清源學(xué)者獎(jiǎng)勵(lì)計(jì)劃”特聘教授，碩士生導(dǎo)師，九三學(xué)社社員，福建省高層次人才，泉州人才“港灣計(jì)劃”引進(jìn)高層次人才（第三層次）。主要從事污染物的健康效應(yīng)及分子毒理學(xué)機(jī)制、典型區(qū)域的環(huán)境微生態(tài)與健康關(guān)系的研究。先后主持和參加各級(jí)科研項(xiàng)目10多項(xiàng)，包括主持國家自然科學(xué)基金項(xiàng)目1項(xiàng)（國家級(jí)）、主持福建省自然科學(xué)基金面上項(xiàng)目2項(xiàng)（省級(jí)）、主持中國科學(xué)院重點(diǎn)實(shí)驗(yàn)室項(xiàng)目2項(xiàng)、主持交通運(yùn)輸部水運(yùn)科學(xué)研究所委托項(xiàng)目1項(xiàng)（橫向）。參與獲評(píng)2021年度福建省科技進(jìn)步三等獎(jiǎng)。目前已在國內(nèi)外環(huán)境領(lǐng)域主流期刊上發(fā)表SCI論文36篇（包括Science of the Total Environment、Environmental Pollution、Chemosphere等Top期刊）。擔(dān)任iMeta期刊青年編委。

代表性論文：

1. Ding, S., Chang, J., Zhang, W., Ji, S., Chi Y*. (2024). Environmental microbial diversity and water pollution characteristics resulted from 150 km coastline in Quanzhou Bay offshore area. Frontiers in Microbiology. 15:1438133.

2. Chi, Y., Zhu, L., Wang, Y., Peng, C., Lin, Y., Ji, S., & Wei, J. (2024). Long-term Bisphenol S exposure induced gut microbiota dysbiosis, obesity, hepatic lipid accumulation, intestinal lesions and dyslipidemia in mice. Toxicology, 153798.

3. Min, L., Chi, Y*., Dong, S*. (2020). Gut microbiota health closely associates with PCB153-derived risk of host diseases. Ecotoxicology and Environmental Safety. 203, 15,111041.

4. Wang, H., Zhao, P., Huang, Q., Chi, Y*., Dong, S*., Fan, J. (2019). Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons. Chemosphere, 229, 618-630.

5. Chi, Y., Lin, Y., Lu, Y., Huang, Q., Ye, G., & Dong, S*. (2019). Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease. Science of the Total Environment, 653, 274-282. 

6. Chi, Y., Lin, Y., Zhu, H., Huang, Q., Ye, G., & Dong, S*. (2018). PCBs-high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice. Environmental Pollution, 239, 332-341. 

7. Chi, Y., Wang, H., Lin, Y., Lu, Y., Huang, Q., Ye, G., & Dong, S*. (2019). Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice. Toxicology, 420, 11-20.

8. Chi, Y., Zhang, H., Huang, Q., Lin, Y., Ye, G., Zhu, H., & Dong, S*. (2018). Environmental risk assessment of selected organic chemicals based on TOC test and QSAR estimation models. Journal of Environmental Sciences, 64, 23-31. 

9. Chi, Y., Huang, Q., Lin, Y., Ye, G., Zhu, H., & Dong, S*. (2018). Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells. Journal of Environmental Sciences, 66, 155-164. 

10. Chi, Y., Huang, Q., Zhang, H., Chen, Y., & Dong, S*. (2016). In situ combined chemical and biological assessment of estrogenic pollution in a water recycling system. Journal of Environmental Sciences, 43, 216-223. 

11. Chi, Y. L., Zhang, H. Y., Xue, J. H., Hao, J., Liu, M. F., & Wei, X. Y*. (2009). N 2-(1-Methoxycarbonylethyl) guanosine, a new nucleoside coupled with an amino acid derivative from Amanita exitialis. Chinese Chemical Letters, 20 (7), 830-832.  

12. Ye, G., Ding, D., Gao, H., Chi, Y., Chen, J., Wu, Z., ... & Dong, S*. (2019). Comprehensive metabolic responses of HepG2 cells to fine particulate matter exposure: Insights from an untargeted metabolomics. Science of The Total Environment, 691, 874-884. 

13. Ding, D., Ye, G., Lin, Y., Lu, Y., Zhang, H., Zhang, X., Hong, Z., Huang, Q., Chi, Y.,... & Dong, S*. (2019). MicroRNA-26a-CD36 signaling pathway: Pivotal role in lipid accumulation in hepatocytes induced by PM2. 5 liposoluble extracts. Environmental Pollution, 248, 269-278. 

14. Ye, G., Gao, H., Wang, Z., Lin, Y., Liao, X., Zhang, H., Chi, Y., Zhu, H., Dong, S*. (2019). PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression. Cell Death & Disease, 10(2), 39-39. 

15. Huang, Q., Liu, Y., Chen, Y., Fang, C., Chi, Y., Zhu, H., ... & Dong, S*. (2018). New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure. Environmental Pollution, 242, 914-921. 

16. Huang, Q., Chen, Y., Lin, L., Liu, Y., Chi, Y., Lin, Y., ... & Dong, S*. (2017). Different effects of bisphenol A and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses. Science of the Total Environment, 595, 752-758. 

17. Lu, Y. Y., Lin, Y., Ding, D. X., Su, S., Chi, Q. Q., Zhang, Y. C., ... & Chi, Y. L. (2017). MiR-26a functions as a tumor suppressor in ambient particulate matter-bound metal-triggered lung cancer cell metastasis by targeting LIN28B–IL6–STAT3 axis. Archives of toxicology, 92:1023-1035. 

18. Lin, Y., Ding, D., Huang, Q., Liu, Q., Lu, H., Liu, Y., Chi, Y., ... & Wei, J*. (2017). Downregulation of miR-192 Causes Hepatic Steatosis and Lipid Accumulation by Inducing SREBF1: Novel Mechanism for Bisphenol A-triggered Non-alcoholic Fatty Liver Disease. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1862(9), 869-882.

詳細(xì)論文鏈接：

https://orcid.org/0000-0002-0443-5189

https://www.researchgate.net/profile/Yulang-Chi

科研項(xiàng)目：

1. 國家自然科學(xué)基金項(xiàng)目，41701576，基于原位魚體暴露研究近岸海域中典型環(huán)境雌激素的生態(tài)毒理效應(yīng)，2018/01-2020/12，28.8萬元，已結(jié)題，主持。

2. “清源學(xué)者獎(jiǎng)勵(lì)計(jì)劃”特聘教授項(xiàng)目，泉師人【2022】9號(hào)，2022/01-2024/12，80萬元，主持。

3. 泉州人才“港灣計(jì)劃”引進(jìn)高層次人才項(xiàng)目（第三層次），F202130065Y，2021/11-2027/11，50萬元，主持。

4. 中國科學(xué)院城市環(huán)境與健康重點(diǎn)實(shí)驗(yàn)室跨組合作項(xiàng)目，KLUEH-C-201901，東南沿海典型城市（區(qū)域）PM2.5的內(nèi)分泌干擾及代謝途徑的健康效應(yīng)研究，2019/03-2021/02，40萬元，已結(jié)題，主持。

5. 中國科學(xué)院城市環(huán)境與健康重點(diǎn)實(shí)驗(yàn)室跨組合作項(xiàng)目，KLUEH-C-201802，砷糖及砷糖磷脂的生物合成機(jī)制、代謝途徑和健康效應(yīng)研究，2018/03-2020/02，40萬元，已結(jié)題，主持。

6. 福建省自然科學(xué)基金面上項(xiàng)目，2018J01022，應(yīng)用原位魚體暴露研究近岸海域典型環(huán)境雌激素的生態(tài)毒理效應(yīng)，2018/04-2021/04，4萬元，已結(jié)題，主持。

7. 泉州師范學(xué)院引進(jìn)人才科研啟動(dòng)費(fèi)，H19041，PCB77暴露對(duì)小鼠腸道微生物及宿主健康的影響，2020/01-2022/12，20萬元，已結(jié)題，主持。

8. 福建省中青年教師教育科研項(xiàng)目，JAT190525，典型多氯聯(lián)苯誘導(dǎo)腸道微生物紊亂和宿主肝臟相關(guān)疾病的研究，2020/01-2021/12，2萬元，已結(jié)題，主持。

9. 交通運(yùn)輸部水運(yùn)科學(xué)研究所委托項(xiàng)目，2021KH16，進(jìn)境船舶壓載艙沉積物攜帶外來浮游植物對(duì)生態(tài)環(huán)境安全的影響實(shí)驗(yàn)研究，2020/06 -2021/06, 7.8萬元，已結(jié)題，主持。

10. 國家自然科學(xué)基金面上項(xiàng)目，21777158，雙酚A暴露經(jīng)由雌激素受體影響谷氨酸能神經(jīng)網(wǎng)絡(luò)發(fā)育及功能的分子機(jī)制，2018/01-2021/12，64萬元，已結(jié)題，參加。

11. 國家自然科學(xué)基金面上項(xiàng)目，21477124，從胰島素信號(hào)轉(zhuǎn)導(dǎo)通路探討BPA促進(jìn)動(dòng)脈粥樣硬化的作用機(jī)制，2015/01-2018/12，86萬元，已結(jié)題，參加。

12. 國家自然科學(xué)基金青年項(xiàng)目，21507128，多平臺(tái)代謝組學(xué)技術(shù)研究苯并芘暴露下肺的代謝紊亂作用機(jī)制，2016/01-2018/12，22萬元，已結(jié)題，參加。

13. 福建省中科院STS計(jì)劃項(xiàng)目，2016T3005，腸道微生態(tài)精準(zhǔn)調(diào)控技術(shù)研發(fā)，2016/08-2019/07，35萬元，已結(jié)題，參加。

14. 福建省自然科學(xué)基金項(xiàng)目， 2017J01028，雙酚A通過microRNA誘發(fā)非酒精性脂肪肝疾病發(fā)生發(fā)展的分子機(jī)制探討，4萬元，2017/04-2020/03，已結(jié)題，參加。

15. 福建省科技計(jì)劃引導(dǎo)性項(xiàng)目， 2018Y0081，沿海區(qū)域環(huán)境指示生物的污染物負(fù)荷數(shù)據(jù)庫構(gòu)建及應(yīng)用，2018/04-2020/04，15萬元，已結(jié)題，參加。

16. 福建省自然科學(xué)基金項(xiàng)目，2018J01020，苯并芘暴露經(jīng)由芳香烴受體誘發(fā)巨噬細(xì)胞脂質(zhì)累積的分子機(jī)制，2018/04-2021/04，4萬元，已結(jié)題，參加。